The effect of cold on pain has been known for a long time. Hippocrates left us with the first written records of the use of ice and snow for pain. Low temperatures have been used by Egyptians since ancient times to alleviate various pains, and the famous physician Avicenna even used low temperatures in preoperative and postoperative pain treatment. During the Napoleonic Wars, surgeons observed that half-frozen soldiers tolerated limb amputation without major problems, with virtually no anesthesia. The use of so-called Cryoanalgesia has improved over time and sophisticated forms of tissue freezing have been developed to affect pain. Today’s devices enable controlled freezing of nerve structures with a long-term effect, but also with complete nerve regeneration at certain time intervals.